Epidermal Nerve Fiber Density Test – Biopsy Sites
Standard Biopsy sites for ENFD Testing
Therapath has established five standard biopsy sites for Epidermal Nerve Fiber Density (ENFD) and Sweat Gland Nerve Fiber Density (SGNFD). These sites allow for the diagnosis of a Small Fiber Neuropathy affecting either the upper or lower extremities in patients 18 and older.
The standard sites include the Proximal Arm, Distal Arm, Thigh, Distal Leg, and Foot. More details are available on our biopsy procedure guide.
The Epidermal Nerve Fiber Density (ENFD) test measures the density of the small sensory nerve fibers in the skin, and the Sweat Gland Nerve Fiber Density (SGNFD) test measures the density of the small autonomic nerve fibers in the sweat glands.1,2 The same biopsy sample can be used for both tests.
The skin biopsy procedure can be performed at the physician’s office and is reimbursed using CPT codes 11100 and 11101.
- Joint T. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. J Peripher Nerv Syst. 2010;15(2):79-92. [PubMed]
- Gibbons C, Illigens B, Wang N, Freeman R. Quantification of sweat gland innervation: a clinical-pathologic correlation. Neurology. 2009;72(17):1479-1486. [PubMed]
Related Articles
Fulgent Genetics Agrees to Acquire Inform Diagnostics and Provides Preliminary First Quarter Revenue Results
Becky Tsai2022-09-04T01:30:08-05:00
Fulgent Genetics agrees to acquire Inform Diagnostics. [Read More]
Washington Post: “Pains, chills, fatigue, vomiting and vertigo plague me. Small fiber neuropathy causes it all.”
Becky Tsai2022-09-04T01:31:05-05:00
This Washington Post article proves the value of definitive small fiber neuropathy testing. [Read More]
Pruritis and Small Fiber Neuropathy
Becky Tsai2022-09-04T01:34:48-05:00
Chronic pruritis (itching sensation) is associated with a number of medical conditions including several neuropathic illnesses. [Read More]
Small Fiber Neuropathy Symptoms
Becky Tsai2022-09-04T01:36:13-05:00
Haupt el al. conducted a long term review (2.5 to 14 years) of patients diagnosed with small fiber neuropathy (SFN) who did not have signs of large fiber neuropathy. [Read More]
Epidermal Nerve Fiber Density Test – Biopsy Sites
Standard Biopsy sites for ENFD Testing
Therapath has established five standard biopsy sites for Epidermal Nerve Fiber Density (ENFD) and Sweat Gland Nerve Fiber Density (SGNFD). These sites allow for the diagnosis of a Small Fiber Neuropathy affecting either the upper or lower extremities in patients 18 and older.
The standard sites include the Proximal Arm, Distal Arm, Thigh, Distal Leg, and Foot. More details are available on our biopsy procedure guide.
The Epidermal Nerve Fiber Density (ENFD) test measures the density of the small sensory nerve fibers in the skin, and the Sweat Gland Nerve Fiber Density (SGNFD) test measures the density of the small autonomic nerve fibers in the sweat glands.1,2 The same biopsy sample can be used for both tests.
The skin biopsy procedure can be performed at the physician’s office and is reimbursed using CPT codes 11100 and 11101.
- Joint T. European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society. J Peripher Nerv Syst. 2010;15(2):79-92. [PubMed]
- Gibbons C, Illigens B, Wang N, Freeman R. Quantification of sweat gland innervation: a clinical-pathologic correlation. Neurology. 2009;72(17):1479-1486. [PubMed]
Related Articles
Fulgent Genetics Agrees to Acquire Inform Diagnostics and Provides Preliminary First Quarter Revenue Results
Becky Tsai2022-09-04T01:30:08-05:00
Fulgent Genetics agrees to acquire Inform Diagnostics. [Read More]
Washington Post: “Pains, chills, fatigue, vomiting and vertigo plague me. Small fiber neuropathy causes it all.”
Becky Tsai2022-09-04T01:31:05-05:00
This Washington Post article proves the value of definitive small fiber neuropathy testing. [Read More]
Pruritis and Small Fiber Neuropathy
Becky Tsai2022-09-04T01:34:48-05:00
Chronic pruritis (itching sensation) is associated with a number of medical conditions including several neuropathic illnesses. [Read More]
Small Fiber Neuropathy Symptoms
Becky Tsai2022-09-04T01:36:13-05:00
Haupt el al. conducted a long term review (2.5 to 14 years) of patients diagnosed with small fiber neuropathy (SFN) who did not have signs of large fiber neuropathy. [Read More]
