Therapath Neuropathology

Updates and News

Washington Post: “Pains, chills, fatigue, vomiting and vertigo plague me. Small fiber neuropathy causes it all.”

This Washington Post article proves the value of definitive small fiber neuropathy testing. According to the patient, who authored the article, the biopsy results “proved my neurologist was right.” The neurologist is a Therapath client: Teena Shetty, MD, with Hospital for Special Surgery in New York City. Read the article

Pruritis and small fiber neuropathy

Chronic pruritis (itching sensation) is associated with a number of medical conditions including several neuropathic illnesses. ENFD can be a valuable tool in the evaluation of patients with chronic neuropathic itching.

Small Fiber Neuropathy Symptoms

Haupt el al. conducted a long term review (2.5 to 14 years) of patients diagnosed with small fiber neuropathy (SFN) who did not have signs of large-fiber neuropathy.1 Patient symptoms included numbness, burning sensation, or reduced vibration sensitivity. Of the twelve patients reviewed, three were later diagnosed with large fiber neuropathy while nine remained stable. […]

Epidermal Nerve Fiber Density Test – Biopsy Sites

Standard Biopsy sites for ENFD Testing Therapath has established five standard biopsy sites for Epidermal Nerve Fiber Density (ENFD) and Sweat Gland Nerve Fiber Density (SGNFD). These sites allow for the diagnosis of a Small Fiber Neuropathy affecting either the upper or lower extremities in patients 18 and older. The standard sites include the Proximal […]

Abstract: Associated conditions in small fiber neuropathy

De Greef et al. studied 921 patients with confirmed small fiber neuropathy in order to investigate the prevalence of associated conditions in SFN patients.

Abstract: Idiopathic Small Fiber Neuropathy in Children

The review concluded that there was evidence of immune-mediated small fiber neuropathy in a high proportion of the cohort.

Abstract: Prediabetes and small fiber neuropathy

117 patients were in included in the study that looked at differences in intraepidermal nerve fiber density for patients in three groups: diabetes mellitus, prediabetes, and normoglycemia.

Abstract: The evaluation of small fiber neuropathy

The survey found that neurologists with a neuromuscular subspecialty were more likely to order a skin biopsy for intraepidermal nerve fiber density.

Systematic review presents current understanding of Small Fiber Neuropathy

The review, published in the May 2016 issue of Muscle & Nerve, provides a comprehensive evaluation of Small Fiber Neuropathy (SFN) research.

New study examines fixative solutions used in skin biopsy test for small fiber neuropathy

Therapath finalized a comparsion study of the most common fixation methods used in Epidermal Nerve Fiber Density. The study concludes that proper fixation technique is critical for test accuracy.