Small Fiber Neuropathy Testingtherapath2022-09-04T01:26:58-05:00

Small Fiber Neuropathy Testing

Therapath provides Epidermal Nerve Fiber Density (ENFD) and Sweat Gland Nerve Fiber Density (SGNFD) testing for the evaluation of Small Fiber Neuropathy. Results are available in 7-10 days.

In-Office Skin Biopsy Procedure

Demonstration of a reduction in the Epidermal Nerve Fiber Density (ENFD) on punch skin biopsy is a highly sensitive and specific test for Small Fiber Neuropathy (SFN).¹Samples are collected using a 3mm punch biopsy.

Skin Biopsy Procedure Guide

Convenient Biopsy Kits

Kits include everything needed for the procedure except lidocaine and a syringe. Collection kits are shipped via overnight service and are temperature controlled to protect samples during transit.

Order Biopsy Kits

Convenient Biopsy Kits

Kits include everything needed for the procedure except lidocaine and a syringe. Collection kits are shipped via overnight service and are temperature controlled to protect samples during transit.

Order Biopsy Kits

Resource Library

Browse our growing resource library and learn more about Small Fiber Neuropathy Testing.

Small Fiber Neuropathy Overview

Symptoms of sensory small fiber neuropathy include numbness, hypersensitivity, and spontaneous painful or annoying sensations called paresthesias.

Epidermal Nerve Fiber Density

Demonstration of a reduction in the Epidermal Nerve Fiber Density (ENFD) on punch skin biopsy is a highly sensitive and specific test for Small Fiber Neuropathy (SFN).

Sweat Gland Nerve Fiber Density

A reduction in the innervation of sweat glands has been reported in a number of conditions that can cause autonomic neuropathy.

Small Fiber Neuropathy in Rheumatological Disorders

Patients with rheumatological disorders can present with a variety of syndromes that can result from Small Fiber Neuropathy (SFN). Several recent studies found that approximately 50% of fibromyalgia patients had reduced Epidermal Nerve Fiber Density (ENFD).

Cancer Related Neuropathy

Neuropathy can result from the underlying cancer, or neurotoxicity of drugs used to treat the tumor.

Statin Neuropathy

Statin neuropathy appears to be associated with axonal degeneration, and affects both large and small fibers.

Neuropathy and Amyloidosis

Neuropathy can be an early manifestation of systemic amyloidosis. Such patients often present with a painful distal and symmetric neuropathy and autonomic symptoms.

References
1. Lauria G, Bakkers M, Schmitz C, et al. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst. 2010;15(3):202-207. [PubMed]

Resource Library

Browse our growing resource library and learn more about Small Fiber Neuropathy Testing.

Small Fiber Neuropathy Overview

Symptoms of sensory small fiber neuropathy include numbness, hypersensitivity, and spontaneous painful or annoying sensations called paresthesias.

Epidermal Nerve Fiber Density

Demonstration of a reduction in the Epidermal Nerve Fiber Density (ENFD) on punch skin biopsy is a highly sensitive and specific test for Small Fiber Neuropathy (SFN).

Sweat Gland Nerve Fiber Density

A reduction in the innervation of sweat glands has been reported in a number of conditions that can cause autonomic neuropathy.

Small Fiber Neuropathy in Rheumatological Disorders

Patients with rheumatological disorders can present with a variety of syndromes that can result from Small Fiber Neuropathy (SFN). Several recent studies found that approximately 50% of fibromyalgia patients had reduced Epidermal Nerve Fiber Density (ENFD).

Cancer Related Neuropathy

Neuropathy can result from the underlying cancer, or neurotoxicity of drugs used to treat the tumor.

Statin Neuropathy

Statin neuropathy appears to be associated with axonal degeneration, and affects both large and small fibers.

Neuropathy and Amyloidosis

Neuropathy can be an early manifestation of systemic amyloidosis. Such patients often present with a painful distal and symmetric neuropathy and autonomic symptoms.

References
1. Lauria G, Bakkers M, Schmitz C, et al. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst. 2010;15(3):202-207. [PubMed]

Small Fiber Neuropathy Testing

Therapath provides Epidermal Nerve Fiber Density (ENFD) and Sweat Gland Nerve Fiber Density (SGNFD) testing for the evaluation of Small Fiber Neuropathy. Results are available in 7-10 days.

In-Office Skin Biopsy Procedure

Demonstration of a reduction in the Epidermal Nerve Fiber Density (ENFD) on punch skin biopsy is a highly sensitive and specific test for Small Fiber Neuropathy (SFN).¹ Samples are collected using a 3mm punch biopsy.

Skin Biopsy Procedure Guide

Laboratory with microscope

Convenient Biopsy Kits

Kits include everything needed for the procedure except lidocaine and a syringe. Collection kits are shipped via overnight service and are temperature controlled to protect samples during transit.

Order Biopsy Kits

Resource Library

Browse our growing resource library and learn more about Small Fiber Neuropathy Testing.

Small Fiber Neuropathy Overview

Symptoms of sensory small fiber neuropathy include numbness, hypersensitivity, and spontaneous painful or annoying sensations called paresthesias.

Epidermal Nerve Fiber Density

Demonstration of a reduction in the Epidermal Nerve Fiber Density (ENFD) on punch skin biopsy is a highly sensitive and specific test for Small Fiber Neuropathy (SFN).

Sweat Gland Nerve Fiber Density

A reduction in the innervation of sweat glands has been reported in a number of conditions that can cause autonomic neuropathy.

Small Fiber Neuropathy in Rheumatological Disorders

Patients with rheumatological disorders can present with a variety of syndromes that can result from Small Fiber Neuropathy (SFN). Several recent studies found that approximately 50% of fibromyalgia patients had reduced Epidermal Nerve Fiber Density (ENFD).

Cancer Related Neuropathy

Neuropathy can result from the underlying cancer, or neurotoxicity of drugs used to treat the tumor.

Statin Neuropathy

Statin neuropathy appears to be associated with axonal degeneration, and affects both large and small fibers.

Neuropathy and Amyloidosis

Neuropathy can be an early manifestation of systemic amyloidosis. Such patients often present with a painful distal and symmetric neuropathy and autonomic symptoms.

References
1. Lauria G, Bakkers M, Schmitz C, et al. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst. 2010;15(3):202-207. [PubMed]

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