Small Fiber Neuropathy Testing

Therapath provides Epidermal Nerve Fiber Density (ENFD) and Sweat Gland Nerve Fiber Density (SGNFD) testing for the evaluation of Small Fiber Neuropathy. Results are available in 7-10 days.

In-Office Skin Biopsy Procedure

Demonstration of a reduction in the Epidermal Nerve Fiber Density (ENFD) on punch skin biopsy is a highly sensitive and specific test for Small Fiber Neuropathy (SFN).Samples are collected using a 3mm punch biopsy.

Skin Biopsy Procedure Guide

Convenient Biopsy Kits

Kits include everything needed for the procedure except lidocaine and a syringe. Collection kits are shipped via overnight service and are temperature controlled to protect samples during transit.

Order Biopsy Kits

Convenient Biopsy Kits

Kits include everything needed for the procedure except lidocaine and a syringe. Collection kits are shipped via overnight service and are temperature controlled to protect samples during transit.

Order Biopsy Kits

Resource Library

Browse our growing resource library and learn more about Small Fiber Neuropathy Testing.

Symptoms of sensory small fiber neuropathy include numbness, hypersensitivity, and spontaneous painful or annoying sensations called paresthesias.

Learn More…

Demonstration of a reduction in the Epidermal Nerve Fiber Density (ENFD) on punch skin biopsy is a highly sensitive and specific test for Small Fiber Neuropathy (SFN).

Learn More…

A reduction in the innervation of sweat glands has been reported in a number of conditions that can cause autonomic neuropathy.

Learn More…

Patients with rheumatological disorders can present with a variety of syndromes that can result from Small Fiber Neuropathy (SFN). Several recent studies found that approximately 50% of fibromyalgia patients had reduced Epidermal Nerve Fiber Density (ENFD).

Learn More…

Neuropathy can result from the underlying cancer, or neurotoxicity of drugs used to treat the tumor.

Learn More…

Statin neuropathy appears to be associated with axonal degeneration, and affects both large and small fibers.

Learn More…

Neuropathy can be an early manifestation of systemic amyloidosis. Such patients often present with a painful distal and symmetric neuropathy and autonomic symptoms.

Learn More…

References
1. Lauria G, Bakkers M, Schmitz C, et al. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst. 2010;15(3):202-207. [PubMed]

Resource Library

Browse our growing resource library and learn more about Small Fiber Neuropathy Testing.

Symptoms of sensory small fiber neuropathy include numbness, hypersensitivity, and spontaneous painful or annoying sensations called paresthesias.

Learn More…

Demonstration of a reduction in the Epidermal Nerve Fiber Density (ENFD) on punch skin biopsy is a highly sensitive and specific test for Small Fiber Neuropathy (SFN).

Learn More…

A reduction in the innervation of sweat glands has been reported in a number of conditions that can cause autonomic neuropathy.

Learn More…

Patients with rheumatological disorders can present with a variety of syndromes that can result from Small Fiber Neuropathy (SFN). Several recent studies found that approximately 50% of fibromyalgia patients had reduced Epidermal Nerve Fiber Density (ENFD).

Learn More…

Neuropathy can result from the underlying cancer, or neurotoxicity of drugs used to treat the tumor.

Learn More…

Statin neuropathy appears to be associated with axonal degeneration, and affects both large and small fibers.

Learn More…

Neuropathy can be an early manifestation of systemic amyloidosis. Such patients often present with a painful distal and symmetric neuropathy and autonomic symptoms.

Learn More…

References
1. Lauria G, Bakkers M, Schmitz C, et al. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst. 2010;15(3):202-207. [PubMed]

Small Fiber Neuropathy Testing

Therapath provides Epidermal Nerve Fiber Density (ENFD) and Sweat Gland Nerve Fiber Density (SGNFD) testing for the evaluation of Small Fiber Neuropathy. Results are available in 7-10 days.

In-Office Skin Biopsy Procedure

Demonstration of a reduction in the Epidermal Nerve Fiber Density (ENFD) on punch skin biopsy is a highly sensitive and specific test for Small Fiber Neuropathy (SFN).1 Samples are collected using a 3mm punch biopsy.

Skin Biopsy Procedure Guide
Laboratory with microscope

Convenient Biopsy Kits

Kits include everything needed for the procedure except lidocaine and a syringe. Collection kits are shipped via overnight service and are temperature controlled to protect samples during transit.

Order Biopsy Kits

Resource Library

Browse our growing resource library and learn more about Small Fiber Neuropathy Testing.

Symptoms of sensory small fiber neuropathy include numbness, hypersensitivity, and spontaneous painful or annoying sensations called paresthesias.

Learn More…

Demonstration of a reduction in the Epidermal Nerve Fiber Density (ENFD) on punch skin biopsy is a highly sensitive and specific test for Small Fiber Neuropathy (SFN).

Learn More…

A reduction in the innervation of sweat glands has been reported in a number of conditions that can cause autonomic neuropathy.

Learn More…

Patients with rheumatological disorders can present with a variety of syndromes that can result from Small Fiber Neuropathy (SFN). Several recent studies found that approximately 50% of fibromyalgia patients had reduced Epidermal Nerve Fiber Density (ENFD).

Learn More…

Neuropathy can result from the underlying cancer, or neurotoxicity of drugs used to treat the tumor.

Learn More…

Statin neuropathy appears to be associated with axonal degeneration, and affects both large and small fibers.

Learn More…

Neuropathy can be an early manifestation of systemic amyloidosis. Such patients often present with a painful distal and symmetric neuropathy and autonomic symptoms.

Learn More…

References
1. Lauria G, Bakkers M, Schmitz C, et al. Intraepidermal nerve fiber density at the distal leg: a worldwide normative reference study. J Peripher Nerv Syst. 2010;15(3):202-207. [PubMed]