Neuropathy and Amyloidosis
Neuropathy can be an early manifestation of systemic amyloidosis. Such patients often present with a painful distal and symmetric neuropathy and autonomic symptoms. It can begin as a small fiber neuropathy and progress to involve the large sensory and motor axons (Yang et al, 2010). Involvement of other organs can also cause myopathy, congestive hear failure, or renal failure.
Biopsy studies can show deposits of amyloid fibrils in the nerves and other tissues, including the skin (Nagasaka et al, 2009). The amyloid fibrils appear as reddish deposits using Congo red staining, and as apple-green birefringence using polarized light microscopy (figure).
Amyloid deposits differ in composition, based on the underlying cause. Primary amyloidosis is associated with monoclonal gammopathy and the amyloid fibrils are made up of fragments of the monoclonal immunoglobulin light chains. (Kissel JT and Mendell JR, 2001). In secondary, or hereditary amyloidosis, the fibrils are composed of mutated proteins, most often transthyretin, and less frequently apoprotein A-1 or gelsolin (Mendell, 2001). Amyloid deposits, once detected, can be typed using immunocytochemistry.
Amyloid deposits can occur in a spotty distribution, so that the absence of amyloid deposits in a skin biopsy does not rule out the diagnosis of amyloid neuropathy. Biopsy of other tissues including abdominal fat, bone marrow, rectal mucosa, or another affected organ, including nerve, may be required to make the diagnosis in individual patients.
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Neuropathy and Amyloidosis
Neuropathy can be an early manifestation of systemic amyloidosis. Such patients often present with a painful distal and symmetric neuropathy and autonomic symptoms. It can begin as a small fiber neuropathy and progress to involve the large sensory and motor axons (Yang et al, 2010). Involvement of other organs can also cause myopathy, congestive hear failure, or renal failure.
Biopsy studies can show deposits of amyloid fibrils in the nerves and other tissues, including the skin (Nagasaka et al, 2009). The amyloid fibrils appear as reddish deposits using Congo red staining, and as apple-green birefringence using polarized light microscopy (figure).
Amyloid deposits differ in composition, based on the underlying cause. Primary amyloidosis is associated with monoclonal gammopathy and the amyloid fibrils are made up of fragments of the monoclonal immunoglobulin light chains. (Kissel JT and Mendell JR, 2001). In secondary, or hereditary amyloidosis, the fibrils are composed of mutated proteins, most often transthyretin, and less frequently apoprotein A-1 or gelsolin (Mendell, 2001). Amyloid deposits, once detected, can be typed using immunocytochemistry.
Amyloid deposits can occur in a spotty distribution, so that the absence of amyloid deposits in a skin biopsy does not rule out the diagnosis of amyloid neuropathy. Biopsy of other tissues including abdominal fat, bone marrow, rectal mucosa, or another affected organ, including nerve, may be required to make the diagnosis in individual patients.
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Neuropathy and Amyloidosis
therapath2022-09-04T01:45:38-05:00
Neuropathy can be an early manifestation of systemic amyloidosis. Such patients often present with a painful distal and symmetric neuropathy and autonomic symptoms. [Read More]
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therapath2022-09-04T14:23:35-05:00
Statin neuropathy appears to be associated with axonal degeneration, and affects both large and small fibers. [Read More]
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therapath2022-09-04T14:22:45-05:00
Neuropathy can result from the underlying cancer, or neurotoxicity of drugs used to treat the tumor. [Read More]
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