Systematic Review Presents Current Understanding of Small Fiber Neuropathy
The review, published in the May 2016 issue of Muscle & Nerve, provides a comprehensive evaluation of Small Fiber Neuropathy (SFN) research.
Few systematic reviews have addressed the emerging topic of SFN over the last decade. In this review we present an up-to date understanding of SFN by addressing epidemiology,etiology, clinical presentation, diagnosis, pathophysiology, treatment, and outcome.
The authors compare several diagnostic methods for SFN and note that epidermal nerve fiber density (ENFD) through punch biopsy is sensitive, reliable, and efficient.1
In discussing etiology, the review highlights the importance of ENFD analysis for fibromyalgia patients.
Identifying SFN in fibromyalgia patients not only provides a specific diagnosis but also increases treatment options.
The review concludes that SFN patients require a “pragmatic workup…to optimize treatment”.1 The full article is available in Muscle & Nerve.
- Chan A, Wilder-Smith E. Small fiber neuropathy: Getting bigger! Muscle Nerve. 2016;53(5):671-682. [PubMed]
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Systematic Review Presents Current Understanding of Small Fiber Neuropathy
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The review, published in the May 2016 issue of Muscle & Nerve, provides a comprehensive evaluation of Small Fiber Neuropathy (SFN) research. [Read More]
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Systematic Review Presents Current Understanding of Small Fiber Neuropathy
The review, published in the May 2016 issue of Muscle & Nerve, provides a comprehensive evaluation of Small Fiber Neuropathy (SFN) research.

Few systematic reviews have addressed the emerging topic of SFN over the last decade. In this review we present an up-to date understanding of SFN by addressing epidemiology,etiology, clinical presentation, diagnosis, pathophysiology, treatment, and outcome.
The authors compare several diagnostic methods for SFN and note that epidermal nerve fiber density (ENFD) through punch biopsy is sensitive, reliable, and efficient.1
In discussing etiology, the review highlights the importance of ENFD analysis for fibromyalgia patients.
Identifying SFN in fibromyalgia patients not only provides a specific diagnosis but also increases treatment options.
The review concludes that SFN patients require a “pragmatic workup…to optimize treatment”.1 The full article is available in Muscle & Nerve.
- Chan A, Wilder-Smith E. Small fiber neuropathy: Getting bigger! Muscle Nerve. 2016;53(5):671-682. [PubMed]
Related Articles
Abstract: The Evaluation of Small Fiber Neuropathy
therapath2022-09-05T17:46:29-05:00
Thawani el al. recently conducted a survey of neurologists regarding their evaluation of patients with small fiber neuropathy. [Read More]
Systematic Review Presents Current Understanding of Small Fiber Neuropathy
therapath2022-09-05T17:47:23-05:00
The review, published in the May 2016 issue of Muscle & Nerve, provides a comprehensive evaluation of Small Fiber Neuropathy (SFN) research. [Read More]
New Study Examines Fixative Solutions Used in Skin Biopsy Test for Small Fiber Neuropathy
therapath2022-09-05T17:48:19-05:00
Therapath LLC finalized a comparison study of the most common fixation methods used in Epidermal Nerve Fiber Density testing for the determination of SFN. [Read More]
Therapath Neuropathology Announces National Ophthalmic Pathology Program
therapath2022-09-05T17:49:10-05:00
Therapath LLC, a leader in neuropathology laboratory services, launches its national ophthalmic pathology program. [Read More]