Neuropathy and Fibromyalgia
Neuropathy Digest Volume III. Selections include: Reduced nerve fiber density in patients with fibromyalgia, and mononeuropathy in complex regional pain syndrome (CRPS).
Oaklander and colleagues (ANA, 2012a) reported on their findings that a substantial number of patients with fibromyalgia have small fiber neuropathy. They measured the intraepidermal nerve fiber densities (IENF) in punch skin biopsies from patients with fibromyalgia and found that 50% had IENF densities below the 5th percentile of normal controls. The IENF density in fibromyalgia patients averaged 24 +/- 0.1% of predicted norm vs. 64 +/- 0.07 % in controls. Autonomic function testing and the Utah Early Neuropathy Scale also pointed to neuropathic changes in many of the fibromyalgia patients. The authors conclude that substantial numbers of fibromyalgia patients meet rigorous diagnostic criteria for small fiber neuropathy, possibly explaining their pain.
Related Articles
Epidermal Nerve Fiber Density Test – Biopsy Sites
therapath2022-09-05T19:02:43-05:00
Therapath has established five standard biopsy sites for Epidermal Nerve Fiber Density (ENFD) and Sweat Gland Nerve Fiber Density (SGNFD). [Read More]
Abstract: Associated Conditions in Small Fiber Neuropathy
therapath2022-09-05T19:01:46-05:00
De Greef et al. studied 921 patients with confirmed small fiber neuropathy in order to investigate the prevalence of associated conditions in SFN patients. [Read More]
Abstract: Idiopathic Small Fiber Neuropathy in Children
therapath2022-09-05T17:30:24-05:00
Balushi, Kim, Krause, and Kafie looked at idiopathic small fiber neuropathy findings in children who had small fiber neuropathy confirmed by history, clinical exam, and low intraepidermal nerve fiber density. [Read More]
Abstract: Prediabetes and Small Fiber Neuropathy
therapath2022-09-05T17:45:25-05:00
Thaisetthawatkul, Fernandes, and Herrmann looked at the connection between prediabetes and small fiber neuropathy. [Read More]
Neuropathy and Fibromyalgia
Neuropathy Digest Volume III. Selections include: Reduced nerve fiber density in patients with fibromyalgia, and mononeuropathy in complex regional pain syndrome (CRPS).
Oaklander and colleagues (ANA, 2012a) reported on their findings that a substantial number of patients with fibromyalgia have small fiber neuropathy. They measured the intraepidermal nerve fiber densities (IENF) in punch skin biopsies from patients with fibromyalgia and found that 50% had IENF densities below the 5th percentile of normal controls. The IENF density in fibromyalgia patients averaged 24 +/- 0.1% of predicted norm vs. 64 +/- 0.07 % in controls. Autonomic function testing and the Utah Early Neuropathy Scale also pointed to neuropathic changes in many of the fibromyalgia patients. The authors conclude that substantial numbers of fibromyalgia patients meet rigorous diagnostic criteria for small fiber neuropathy, possibly explaining their pain.
Related Articles
Epidermal Nerve Fiber Density Test – Biopsy Sites
therapath2022-09-05T19:02:43-05:00
Therapath has established five standard biopsy sites for Epidermal Nerve Fiber Density (ENFD) and Sweat Gland Nerve Fiber Density (SGNFD). [Read More]
Abstract: Associated Conditions in Small Fiber Neuropathy
therapath2022-09-05T19:01:46-05:00
De Greef et al. studied 921 patients with confirmed small fiber neuropathy in order to investigate the prevalence of associated conditions in SFN patients. [Read More]
Abstract: Idiopathic Small Fiber Neuropathy in Children
therapath2022-09-05T17:30:24-05:00
Balushi, Kim, Krause, and Kafie looked at idiopathic small fiber neuropathy findings in children who had small fiber neuropathy confirmed by history, clinical exam, and low intraepidermal nerve fiber density. [Read More]
Abstract: Prediabetes and Small Fiber Neuropathy
therapath2022-09-05T17:45:25-05:00
Thaisetthawatkul, Fernandes, and Herrmann looked at the connection between prediabetes and small fiber neuropathy. [Read More]
